Therapy or Treatment of Hashimoto's Disease

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Evidence-based MEDLINE Search:

The articles cited below represent current clinical research related to the therapy or treatment of Hashimoto's Disease.  This search was conducted November 18, 1998 on the 1995-1998 portion of the MEDLINE database.
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To update this search with more recent literature, search MEDLINE using our Search Strategy, below, or search the subject heading thyroiditis, autoimmune and clinical trial as a publication type.  MEDLINE is available free through PUBMED.
 

Search Results

     1. Hsi ED. Singleton TP. Svoboda SM. Schnitzer B. Ross CW. Characterization of the lymphoid infiltrate in Hashimoto thyroiditis by immunohistochemistry and polymerase chain reaction for immunoglobulin heavy chain gene rearrangement. [Journal Article] American Journal of Clinical Pathology. 110(3):327-33, 1998 Sep.

    2. Mussa GC. Corrias A. Mostert M. Pellegrino D. Silvestro L. Patients with Hashimoto's disease treated with L-thyroxine and followed for three years. [Clinical Trial. Journal Article] Journal of Pediatric Endocrinology & Metabolism. 11(1):59-62, 1998 Jan-Feb.

    3. Itoh M. Uchimura K. Hayakawa N. Makino M. Hayashi R. Nagata M. Kakizawa H. Nagasaka A. Sakamoto H. Kuzuya H. Surface expression and release of soluble forms of CD8 and CD23 in CD40- and IL-4-activated mononuclear cells from patients with Graves' disease (GD). [Journal Article] Clinical & Experimental Immunology. 113(2):309-14, 1998 Aug.

    4. de Luis DA. Varela C. de La Calle H. Canton R. de Argila CM. San Roman AL. Boixeda D. Helicobacter pylori infection is markedly increased in patients with autoimmune atrophic thyroiditis. [Journal Article] Journal of Clinical Gastroenterology. 26(4):259-63, 1998 Jun.

    5. Zukowski TH. Jorgensen RA. Dickson ER. Lindor KD. Autoimmune conditions associated with primary biliary cirrhosis: response to ursodeoxycholic acid therapy. [Clinical Trial. Journal Article. Randomized Controlled Trial] American Journal of Gastroenterology. 93(6):958-61, 1998 Jun.

    6. Morgenthaler NG. Pampel I. Aust G. Seissler J. Scherbaum WA. Application of a bioassay with CHO cells for the routine detection of stimulating and blocking autoantibodies to the TSH-receptor. [Journal Article] Hormone & Metabolic Research. 30(3):162-8, 1998 Mar.

    7. Botero D. Brown RS. Bioassay of thyrotropin receptor antibodies with Chinese hamster ovary cells transfected with recombinant human thyrotropin receptor: clinical utility in children and adolescents with Graves disease [see comments]. [Journal Article] Journal of Pediatrics. 132(4):612-8, 1998 Apr.

    8. Olivieri A. Magnani F. Valensise H. D'Archivio M. Medda E. Baccarini S. Sorcini M.  Romanini C. Thyroid autoimmunity in pregnant women at risk for GDM. [Clinical Trial. Journal Article] Annali dell Istituto Superiore di Sanita. 33(3):447-50, 1997.

    9. Gonzalez-Jimenez A. Fernandez-Soto ML. Lobon-Hernandez JA. Lopez-Medina JA. Navarrete L. Escobar-Jimenez F. Autoimmune thyroid disease and insulin-dependent diabetes mellitus during pregnancy and post partum. [Clinical Trial. Journal Article] Annali dell Istituto Superiore di Sanita. 33(3):437-9, 1997.

    10. Lee S. Scherberg N. DeGroot LJ. Induction of oral tolerance in human autoimmune thyroid disease. [Clinical Trial. Journal Article. Randomized Controlled Trial] Thyroid. 8(3):229-34, 1998 Mar.

    11. Schuppert F. Rambusch E. Kirchner H. Atzpodien J. Kohn LD. von zur Muhlen A. Patients treated with interferon-alpha, interferon-beta, and interleukin-2 have a different thyroid autoantibody pattern than patients suffering from endogenous autoimmune thyroid disease. [Clinical Trial. Controlled Clinical Trial. Journal Article] Thyroid. 7(6):837-42, 1997 Dec.

    12. Pietropaolo M. Peakman M. Pietropaolo SL. Zanone MM. Foley TP Jr. Becker DJ. Trucco M. Combined analysis of GAD65 and ICA512(IA-2) autoantibodies in organ and non-organ-specific autoimmune diseases confers high specificity for insulin-dependent diabetes mellitus. [Journal Article] Journal of Autoimmunity. 11(1):1-10, 1998 Feb.

    13. Khoo DH. Fok AC. Tan CE. Koh LK. Lim SC. Eng PH. Ho SC. Thyroid stimulating hormone receptor antibody levels in Singaporean patients with autoimmune thyroid disease. [Clinical Trial. Controlled Clinical Trial. Journal Article] Annals of the Academy of Medicine, Singapore. 26(4):435-8, 1997 Jul.

    14. Wan Q. McCormick DJ. David CS. Kong YC. Thyroglobulin peptides of specific primary hormonogenic sites can generate cytotoxic T cells and serve as target autoantigens in experimental autoimmune thyroiditis. [Journal Article] Clinical Immunology & Immunopathology. 86(1):110-4, 1998 Jan.

    15. Yarman S. Mudun A. Alagol F. Tanakol R. Azizlerli H. Oguz H. Cantez S. Scintigraphic varieties in Hashimoto's thyroiditis and comparison with ultrasonography. [Clinical Trial. Journal Article] Nuclear Medicine Communications. 18(10):951-6, 1997 Oct.

    16. Damotte D. Colomb E. Cailleau C. Brousse N. Charreire J. Carnaud C. Analysis of susceptibility of NOD mice to spontaneous and experimentally induced thyroiditis. [Journal Article] European Journal of Immunology. 27(11):2854-62, 1997 Nov.

    17. Akamine H. Komiya I. Shimabukuro T. Asawa T. Tanaka H. Yagi N. Taira T. Nagata K. Arakaki K. Wakugami T. Takasu N. Powell MJ. Furmaniak J. Smith BR. High prevalence of GAD65 (and IA-2) antibodies in Japanese IDDM patients by a new immunoprecipitation assay based on recombinant human GAD65. [Journal Article] Diabetic Medicine. 14(9):778-84, 1997 Sep.

    18. Pacini F. Vorontsova T. Demidchik EP. Molinaro E. Agate L. Romei C. Shavrova E. Cherstvoy ED. Ivashkevitch Y. Kuchinskaya E. Schlumberger M. Ronga G. Filesi M. Pinchera A. Post-Chernobyl thyroid carcinoma in Belarus children and adolescents: comparison with naturally occurring thyroid carcinoma in Italy and France. [Journal Article] Journal of Clinical Endocrinology & Metabolism. 82(11):3563-9, 1997 Nov.

    19. Watanabe M. Amino N. Hochito K. Watanabe K. Kuma K. Iwatani Y. Opposite changes  in serum soluble CD8 in patients at the active stages of Graves' and Hashimoto's diseases. [Journal Article] Thyroid. 7(5):743-7, 1997 Oct.

    20. Rao VP. Carayanniotis G. Contrasting immunopathogenic properties of highly homologous peptides from rat and human thyroglobulin. [Journal Article] Immunology. 90(2):244-9, 1997 Feb.

    21. Kabadi UM. Influence of age on optimal daily levothyroxine dosage in patients with primary hypothyroidism grouped according to etiology. [Journal Article] Southern Medical Journal. 90(9):920-4, 1997 Sep.

    22. Metcalfe RA. Ball G. Kudesia G. Weetman AP. Failure to find an association between hepatitis C virus and thyroid autoimmunity. [Clinical Trial. Journal Article] Thyroid. 7(3):421-4, 1997 Jun.

    23. Vitti P. Rago T. Chiovato L. Pallini S. Santini F. Fiore E. Rocchi R. Martino E. Pinchera A. Clinical features of patients with Graves' disease undergoing remission after antithyroid drug treatment. [Clinical Trial. Journal Article] Thyroid. 7(3):369-75, 1997 Jun.

    24. Kaczur V. Vereb G. Molnar I. Krajczar G. Kiss E. Farid NR. Balazs C. Effect of anti-thyroid peroxidase (TPO) antibodies on TPO activity measured by chemiluminescence assay. [Journal Article] Clinical Chemistry. 43(8 Pt 1):1392-6, 1997 Aug.

    25. Clofent-Sanchez G. Laroche-Trainean J. Lucas S. Rispal P. Pellegrin JL. Nurden P. Nurden A. Incidence of anti-mouse antibodies in thrombocytopenic patients with autoimmune disorders. [Journal Article] Human Antibodies. 8(2):50-9, 1997.

    26. Notsu K. Ito Y. Furuya H. Ohguni S. Kato Y. Incidence of hyperprolactinemia in patients with Hashimoto's thyroiditis. [Journal Article] Endocrine Journal. 44(1):89-94, 1997 Feb.

    27. Loviselli A. Sammartano L. Mastinu GL. Secchi FM. Porcu A. Tanda F. Mariotti S. Parathyroid carcinoma and primary autoimmune hypothyroidism in an elderly woman. [Journal Article] Journal of Endocrinological Investigation. 20(2):82-5, 1997 Feb.

    28. Akcay G. Uslu H. Varoglu E. Tekin SB. Gundogdu C. Assessment of thyroid nodules by technetium-99m-tetrofosmin scintigraphy. [Journal Article] British Journal of Clinical Practice. 51(1):5-7, 1997 Jan-Feb.

    29. Krassas GE. Kaltsas T. Dumas A. Pontikides N. Tolis G. Lanreotide in the treatment of patients with thyroid eye disease. [Clinical Trial. Journal Article] European Journal of Endocrinology. 136(4):416-22, 1997 Apr.

    30. LoPresti JS. Laboratory tests for thyroid disorders. [Review] [44 refs] [Journal Article. Review. Review, Tutorial] Otolaryngologic Clinics of North America. 29(4):557-75, 1996 Aug.

    31. Kim TG. Carrington M. Choi HB. Kim HY. Han H. Three HLA-DMB variants in Korean patients with autoimmune diseases. [Journal Article] Human Immunology. 46(1):58-60, 1996 Mar.

    32. Kasagi K. Kousaka T. Higuchi K. Iida Y. Misaki T. Alam MS. Miyamoto S. Yamabe H. Konishi J. Clinical significance of measurements of antithyroid antibodies in the diagnosis of Hashimoto's thyroiditis: comparison with histological findings. [Journal Article] Thyroid. 6(5):445-50, 1996 Oct.

    33. Dai J. Dent W. Atkinson JW. Cox JG. Dembinski TC. Comparison of three immunoassay kits for serum thyroglobulin in patients with thyroid cancer. [Journal Article] Clinical Biochemistry. 29(5):461-5, 1996 Oct.

    34. Fukata S. Kuma K. Sugawara M. Relationship between cigarette smoking and hypothyroidism in patients with Hashimoto's thyroiditis. [Journal Article] Journal of Endocrinological Investigation. 19(9):607-12, 1996 Oct.

    35. Yeh HC. Futterweit W. Gilbert P. Micronodulation: ultrasonographic sign of Hashimoto thyroiditis. [Journal Article] Journal of Ultrasound in Medicine. 15(12):813-9, 1996 Dec.

    36. Sunthornthepvarakul T. Kitvitayasak S. Ngowngarmratana S. Konthong P. Deerochanawong C. Sarinnapakorn V. Phongviratchai S. Simple and sensitive test for thyroid hormone autoantibodies. [Journal Article] Journal of the Medical Association of Thailand. 79(11):722-6, 1996 Nov.

    37. Signore A. Picarelli A. Chianelli M. Biancone L. Annovazzi A. Tiberti C. Anastasi E. Multari G. Negri M. Pallone F. Pozzilli P. I-interleukin-2 scintigraphy: a new approach to assess disease activity in autoimmunity. [Journal Article] Journal of Pediatric Endocrinology & Metabolism. 9 Suppl 1:139-44, 1996 Mar.

    38. Bhatia SK. Rose NR. Schofield B. Lafond-Walker A. Kuppers RC. Influence of diet on the induction of experimental autoimmune thyroid disease. [Journal Article] Proceedings of the Society for Experimental Biology & Medicine. 213(3):294-300, 1996 Dec.

    39. Podoloff DA. Is there a place for routine surveillance using sonography, CT, or MR imaging for early detection (notably lymphoma) of patients affected by Hashimoto's thyroiditis?. [Journal Article] AJR. American Journal of Roentgenology. 167(5):1337-8, 1996 Nov.

    40. Heuer M. Aust G. Ode-Hakim S. Scherbaum WA. Different cytokine mRNA profiles in Graves' disease, Hashimoto's thyroiditis, and nonautoimmune thyroid disorders determined by quantitative reverse transcriptase polymerase chain reaction (RT-PCR). [Clinical Trial. Journal Article] Thyroid. 6(2):97-106, 1996 Apr.

    41. Campbell J. Day P. Diamond T. Fine adjustments in thyroxine replacement and its effect on bone metabolism. [Clinical Trial. Journal Article] Thyroid. 6(2):75-8, 1996 Apr.

    42. Vrbikova J. Janatkova I. Zamrazil V. Tomiska F. Fucikova T. Epstein-Barr virus serology in patients with autoimmune thyroiditis. [Journal Article] Experimental & Clinical Endocrinology & Diabetes. 104(1):89-92, 1996.

    43. Endo T. Kogai T. Nakazato M. Saito T. Kaneshige M. Onaya T. Autoantibody against Na+/I- symporter in the sera of patients with autoimmune thyroid disease. [Journal Article] Biochemical & Biophysical Research Communications. 224(1):92-5, 1996 Jul 5.

    44. Bryhni B. Aanderud S. Sundsfjord J. Rekvig OP. Jorde R. Thyroid antibodies in northern Norway: prevalence, persistence and relevance. [Journal Article] Journal of Internal Medicine. 239(6):517-23, 1996 Jun.

    45. Lomo LC. Motte RW. Giraldo AA. Nabozny GH. David CS. Rimm IJ. Kong YM. V beta 8.2 transgene expression interferes with development of experimental autoimmune thyroiditis in CBA k/q but not k/k mice. [Journal Article] Cellular Immunology. 168(2):297-301, 1996 Mar 15.

    46. Arscott PL. Koenig RJ. Kaplan MM. Glick GD. Baker JR Jr. Unique autoantibody epitopes in an immunodominant region of thyroid peroxidase. [Journal Article] Journal of Biological Chemistry. 271(9):4966-73, 1996 Mar 1.

    47. Perry A. Molberg K. Albores-Saavedra J. Physiologic versus neoplastic C-cell hyperplasia of the thyroid: separation of distinct histologic and biologic entities. [Journal Article] Cancer. 77(4):750-6, 1996 Feb 15.

    48. Mansi L. Rambaldi PF. Bizzarro A. Panza N. Del Vecchio E. 111In-octreotide in the evaluation of autoimmune thyroid diseases. [Journal Article] Quarterly Journal of Nuclear Medicine. 39(4 Suppl 1):127-30, 1995 Dec.

    49. Odawara M. Asano M. Yamashita K. Mitochondrial gene mutations that affect the binding of the termination factor and their prevalence among Japanese diabetes mellitus. [Journal Article] Nucleic Acids Symposium Series. (34):237-8, 1995.

    50. Colls J. Betterle C. Volpato M. Prentice L. Smith BR. Furmaniak J. Immunoprecipitation assay for autoantibodies to steroid 21-hydroxylase in autoimmune adrenal diseases [see comments]. [Journal Article] Clinical Chemistry. 41(3):375-80, 1995 Mar.

    51. Winand RJ. Winand-Devigne J. Cox C. Caulier C. Meurisse M. Simple radioimmunological assay of anti-alpha-galactosyl antibody (anti-Gal): application to autoimmune thyroid diseases and thyroid-associated ophthalmopathy. [Journal Article] Journal of Endocrinological Investigation. 18(10):749-53, 1995 Nov.

    52. Pirro MT. De Filippis V. Di Cerbo A. Scillitani A. Liuzzi A. Tassi V. Thyroperoxidase microsatellite polymorphism in thyroid diseases. [Clinical Trial. Journal Article] Thyroid. 5(6):461-4, 1995 Dec.

    53. Tassi V. Scarnecchia L. Di Cerbo A. Pirro MT. Di Paola R. Liuzzi A. Torlontano M. Zingrillo M. D'Aloiso L. De Filippis V. A thyroid hormone receptor beta gene polymorphism associated with Graves' disease. [Journal Article] Journal of Molecular Endocrinology. 15(3):267-72, 1995 Dec.

    54. Vitti P. Rago T. Mazzeo S. Brogioni S. Lampis M. De Liperi A. Bartolozzi C. Pinchera A. Martino E. Thyroid blood flow evaluation by color-flow Doppler sonography distinguishes Graves' disease from Hashimoto's thyroiditis. [Clinical Trial. Journal Article] Journal of Endocrinological Investigation. 18(11):857-61, 1995 Dec.

    55. Berho M. Suster S. Clear nuclear changes in Hashimoto's thyroiditis. A clinicopathologic study of 12 cases. [Journal Article] Annals of Clinical & Laboratory Science. 25(6):513-21, 1995 Nov-Dec.
 
    56. Tsai RT. Chang TC. Wang CR. Lee SL. Wang CJ. Tsay GJ. Thyroid peroxidase autoantibodies and their effects on enzyme activity in patients with systemic lupus erythematosus. [Journal Article] Lupus. 4(4):280-5, 1995 Aug.

    57. Carella C. Amato G. Biondi B. Rotondi M. Morisco F. Tuccillo C. Chiuchiolo N. Signoriello G. Caporaso N. Lombardi G. Longitudinal study of antibodies against thyroid in patients undergoing interferon-alpha therapy for HCV chronic hepatitis. [Clinical Trial. Journal Article] Hormone Research. 44(3):110-4, 1995.

    58. Cho BY. Kim WB. Chung JH. Yi KH. Shong YK. Lee HK. Koh CS. High prevalence and little change in TSH receptor blocking antibody titres with thyroxine and antithyroid drug therapy in patients with non-goitrous autoimmune thyroiditis. [Journal Article] Clinical Endocrinology. 43(4):465-71, 1995 Oct.

    59. Kaveri S. Epitope and idiotope mapping using monoclonal antibodies. [Journal Article] Methods in Molecular Biology. 51:171-81, 1995.

    60. Paolieri F. Pronzato C. Battifora M. Fiorino N. Canonica GW. Bagnasco M. Infiltrating gamma/delta T-cell receptor-positive lymphocytes in Hashimoto's thyroiditis, Graves' disease and papillary thyroid cancer. [Journal Article] Journal of Endocrinological Investigation. 18(4):295-8, 1995 Apr.

    61. Ueda Y. Sugawa H. Akamizu T. Okuda J. Ueda M. Kosugi S. Ohta C. Kihou Y. Mori T. Thyroid-stimulating antibodies in sera from patients with Graves' disease are heterogeneous in epitope recognition [see comments]. [Journal Article] European Journal of Endocrinology. 132(1):62-8, 1995 Jan.

    62. Yokoi K. Kawai H. Akaike M. Mine H. Saito S. Presence of human T-lymphotropic virus type II-related genes in DNA of peripheral leukocytes from patients with autoimmune thyroid diseases. [Journal Article] Journal of Medical Virology. 45(4):392-8, 1995 Apr.

    63. Schloot N. Eisenbarth GS. Isohormonal therapy of endocrine autoimmunity. [Review] [47 refs] [Journal Article. Review. Review, Tutorial] Immunology Today. 16(6):289-94, 1995 Jun.

    64. Gessl A. Wilfing A. Agis H. Steiner G. Czernin S. Boltz-Nitulescu G. Vierhapper H. Waldhausl W. Activated naive CD4+ peripheral blood T cells in autoimmune thyroid disease. [Clinical Trial. Journal Article] Thyroid. 5(2):117-25, 1995 Apr.

    65. Sato A. Aizawa T. Koizumi Y. Komiya I. Ichikawa K. Takemura Y. Yamada T. Ten-year follow-up study of thyroid function in euthyroid patients with simple goiter or Hashimoto's thyroiditis. [Journal Article] Internal Medicine. 34(5):371-5, 1995 May.

    66. Green LM. Lazarus JP. LaBue M. Shah MM. Reduced cell-cell communication in a spontaneous murine model of autoimmune thyroid disease. [Journal Article] Endocrinology. 136(8):3611-8, 1995 Aug.

    67. Murakami M. Miyashita K. Kakizaki S. Saito S. Yamada M. Iriuchijima T. Takeuchi T. Mori M. Clinical usefulness of thyroid-stimulating antibody measurement using Chinese hamster ovary cells expressing human thyrotropin receptors. [Journal Article] European Journal of Endocrinology. 133(1):80-6, 1995 Jul.

    68. Lee JH. An MA. Jeon JS. Song CU. Shong M. Kim YK. Ro HK. Circulating intercellular adhesion molecule-1(ICAM-1) in sera of patients with Graves' disease and Hashimoto disease. [Journal Article] Korean Journal of Internal Medicine. 10(1):10-5, 1995 Jan.

    69. Badenhoop K. Walfish PG. Rau H. Fischer S. Nicolay A. Bogner U. Schleusener H. Usadel KH. Susceptibility and resistance alleles of human leukocyte antigen (HLA) DQA1 and HLA DQB1 are shared in endocrine autoimmune disease. [Journal Article] Journal of Clinical Endocrinology & Metabolism. 80(7):2112-7, 1995 Jul.

    70. Comtois R. Faucher L. Lafleche L. Outcome of hypothyroidism caused by Hashimoto's thyroiditis. [Clinical Trial. Journal Article] Archives of Internal Medicine. 155(13):1404-8, 1995 Jul 10.

    71. Radetti G. Paganini C. Crepaz R. Pittscheider W. Gentili L. Cardiovascular effects of long-term L-thyroxine therapy for Hashimoto's thyroiditis in children and adolescents. [Clinical Trial. Controlled Clinical Trial. Journal Article] European Journal of Endocrinology. 132(6):688-92, 1995 Jun.

    72. Chikuba N. Akazawa S. Yamaguchi Y. Kawasaki E. Takino H. Yoshimoto M. Ohe N. Yamashita K. Yano A. Nagataki S. Immunogenetic heterogeneity in type 1 (insulin-dependent) diabetes among Japanese--class II antigen and autoimmune thyroid disease. [Journal Article] Diabetes Research & Clinical Practice. 27(1):31-7, 1995 Jan.

    73. Bedin C. Ropars A. Mignon-Godefroy K. Charreire J. Molecular heterogeneity of antigen- or idiotype-induced anti-thyroglobulin monoclonal autoantibodies. [Journal Article] Clinical & Experimental Immunology. 100(3):463-9, 1995 Jun.

    74. Martin S. Kardorf J. Schulte B. Lampeter EF. Gries FA. Melchers I. Wagner R. Bertrams J. Roep BO. Pfutzner A. Autoantibodies to the islet antigen ICA69 occur in IDDM and in rheumatoid arthritis [see comments]. [Journal Article] Diabetologia. 38(3):351-5, 1995 Mar.

    75. Kendall-Taylor P. Investigation of thyrotoxicosis. [Journal Article] Clinical Endocrinology. 42(3):309-13, 1995 Mar.

    76. Kochanska-Dziurowicz A. Starzewski JJ. Dunal W. Estimation of the value of serum beta 2-microglobulin concentration in the diagnosis of Hashimoto' disease. [Journal Article] Clinica Chimica Acta. 233(1-2):101-4, 1995 Jan 16.

    77. Hall RC. Dunlap PK. Hall RC. Pacheco CA. Blakey RK. Abraham J. Thyroid disease and abnormal thyroid function tests in women with eating disorders and depression. [Journal Article] Journal of the Florida Medical Association. 82(3):187-92, 1995 Mar.

    78. Takashima S. Nomura N. Noguchi Y. Matsuzuka F. Inoue T. Primary thyroid lymphoma: evaluation with US, CT, and MRI. [Journal Article] Journal of Computer Assisted Tomography. 19(2):282-8, 1995 Mar-Apr.
 

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Evidence-based Filter for Therapy

This "gold standard" search strategy was refined and updated by the Miner Library Reference librarians, University of Rochester Medical Center, from searches developed by Ann McKibbon and Cindy Walker-Dilks of McMaster University.    It may be found at http://www.urmc.rochester.edu/Miner/Educ/Classes.html.

   1   exp research design/
   2   exp clinical trials/
   3   comparative study/ or placebos/
   4   multicenter study.pt.
   5   clinical trial$1.pt.
   6   exp epidemiologic research design/
   7   random$.ti, ab.
   8   (double blind$ or triple blind$3).ti,ab.
   9   placebo$.ti, ab.
  10   (clinical adj trial$1).ti, ab.
  11   (controlled clinical trial or randomized controlled trial).pt.
  12   practice guideline.pt.
  13  feasibility studies/
  14  clinical protocols/
  15  exp treatment outcome/
  16  or/1-15
  17  Thyroiditis, autoimmune/
  18  16 and 17
  19  limit 18 to english language
 

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